Small study finds low dose Testosterone, 5 mg over 12 weeks, reduced exercise induce myocardial ischemia through an increase in time to ST segment depression.
Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model. Hg has been shown to both inhibit NO synthase and increase COX.
low dose, chronic exposure induces ROS and decreased NO availability. This decrease in NO will result in increase vasoconstriction. This will have localized effects and will result in increased central pressure as a result of the increased peripheral pressure. In addition, inhibition of COMT will result in increase in catecholeamines.
Normalized-TRT group had significantly fewer deaths than no-TRT
Mortality was also significantly lower in the non-normalized-TRT group compared with those in no-TRT group
the normalized-TRT group was associated with significantly increased all-cause mortality-free survival (log-rank, P < 0.05) compared with the non-normalized-TRT or no-TRT groups
normalized-TRT group showed lower risk of MI than non-normalized-TRT (HR: 0.82, CI 0.71–0.95, P = 0.008) and no-TRT
normalized-TRT group had significantly lower stroke events compared with non-normalized-TRT (HR: 0.70, CI 0.51–0.96, P = 0.028) and no-TRT
study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes
retrospective study
the first study to demonstrate that significant benefit is observed only if the dose is adequate to normalize the TT levels
Patients who failed to achieve the therapeutic range after TRT did not see a reduction in MI or stroke and had significantly less benefit on mortality
selected patients without any previous history of MI or stroke prior to initiation of TRT to reduce bias related to CV outcomes
currently only half of the men on TRT had been diagnosed with hypogonadism.
25% of users did not have their T concentrations tested prior to initiating therapy, and 21% of those prescribed TRT did not have their levels tested at any time during treatment.
men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
We demonstrate that 5-methyltetrahydrofolate binds the active site of nitric oxide synthase and mimics the orientation of tetrahydrobiopterin
5-methyltetrahydrofolate attenuates superoxide production (induced by inhibition of tetrahydrobiopterin synthesis) and improves endothelial function
e suggest that 5-methyltetrahydrofolate directly interacts with nitric oxide synthase to promote nitric oxide (vs. superoxide) production and improve endothelial function
Study finds strong correlation between Apo B and Apo B:apo A1 in fatal MI risk in men and women. Apo B was a stronger than LDL in predicting risk in men and women. Apo A1 was noted to be protective, but the stats were less strong.
low vitamin D predicts increased risk of Major adverse cardiac and/or cerebrovascular events after cardiac surgery. The definition of low D was <30. A better study would have been to stratify by 10s the risk.
Another study regarding reverse T3 that many Endocrinologists need to read. In this study, the authors find that significantly higher reverse T3 levels were associated with myocardial function impairment (MFI) class IV. This MFI class IV was also found associated with a decreased fT3/rT3.
Testosterone therapy in older men found to provide no increase in MI risk. In fact, those men with high MI risk, Testosterone provided protection against MI.
wine, red and white, with a mediterranean diet reduced cardiometabolic risk in individuals with diabetes. The volume of nightly intake of wine was 5 oz.